COVID-19 Disease Map
We aim to establish a knowledge repository of molecular mechanisms of COVID-19 as a broad community-driven effort.
Here we share resources and best practices to develop a COVID-19 Disease Map of these mechanisms.
The COVID-19 Disease Map is an assembly of molecular interaction diagrams, established based on literature evidence.
We focus on host-pathogen interactions specific to the SARS-CoV-2 virus.
FAIRDOMHub project space lists our contributors, data and computational models, and literature.
COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms. Ostaszewski M, Mazein A, Gillespie ME, Kuperstein I, Niarakis A, Hermjakob H, Pico AR, Willighagen EL, Evelo CT, Hasenauer J, Schreiber F, Dräger A, Demir E, Wolkenhauer O, Furlong LI, Barillot E, Dopazo J, Orta-Resendiz A, Messina F, Valencia A, Funahashi A, Kitano H, Auffray C, Balling R, Schneider R. Sci Data. 2020 May 5;7(1):136. doi: 10.1038/s41597-020-0477-8. PubMed PMID: 32371892.
Please use this Google Sheet form to let us know how would you like to contribute to the development of the map.
Subscribe to our mailing list for updates and discussions.
More details about the project can be found in our ‘welcome pack’.
We share interesting COVID-19 articles using a Zotero group. The group is public-by-invitation to allow file sharing.
Check curation guidelines
to harmonize your content for easier sharing and integration. The guidelines contain information about regular TCs where we discuss our progress.
Curated diagrams and code are shared using our public Gitlab repository.
Access with your GitHub login and request developer privileges, or contact
WikiPathways can be shared using a dedicated collection with COVID-19 related pathways.
A weekly build is available on the MINERVA Platform.
Relevant databases, literature and datasets can be found on the resources page.
- Reactome pathways for Influenza and HCMV.
- Influenza Lifecycle Pathway Map, aka FluMap, for easy browsing go here.
- 221 pathway diagrams extracted from CORD-19 dataset are available here.
- a recent Nature paper on the SARS-CoV-2 - human interactome, interactions between human candidates from Pathway Commons, compiled by Ozgun Babur can be found here.