How to browse COVID-19 Disease Map diagrams:
| Pathway | Diagrams | Virus proteins | |
|---|---|---|---|
| Resource | Access | ||
|
Virus replication cycle: Attachment and entry |
WikiPathways | WP4846 | All |
| Reactome | R-HSA-9678110, R-HSA-9694614 | ||
| MINERVA (GitLab) | Virus replication cycle (GitLab) | ||
|
Virus replication cycle: Transcription, translation and replication |
WikiPathways | WP4846 | All |
| Reactome |
R-HSA-9679504, R-HSA-9694676 R-HSA-9679514, R-HSA-9694682 R-HSA-9683701, R-HSA-9694635 |
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| MINERVA (GitLab) |
Virus replication cycle
(GitLab) RTC and transcription (GitLab) Nsp9 interactions (GitLab) E protein interactions (GitLab) |
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|
Virus replication cycle: Assembly and release |
Reactome | R-HSA-9679509, R-HSA-9694322 | All |
| MINERVA (GitLab) |
Virus replication cycle
(GitLab) Nsp4 and Nsp6 interactions (GitLab) |
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|
Viral subversion of host defence: ER stress and unfolded protein response |
WikiPathways | WP4861 |
S (HCoV OC43) 4a (MERS) Orf8ab, E, nsp15 (SARS-CoV-1) |
| MINERVA (GitLab) | ER stress (GitLab) | ||
|
Viral subversion of host defence: Autophagy and protein degradation |
WikiPathways | WP4860, WP4936, WP4863 |
nsp6 (SARS-CoV-1) nsp567 (PRRSV) Nsp6, Orf3, Orf10 (SARS-CoV-2) |
| MINERVA (GitLab) | Orf10 Cul2 pathway (GitLab) | ||
|
Viral subversion of host defence: Apoptosis |
WikiPathways | WP4864 |
Orf3a, Orf3b, Orf6, Orf8a, Orf7a, Orf9b, E, M, N, S (SARS-CoV-1) Nsp4. Nsp5, Nsp6. Nsp7, Nsp8, Orf9c (SARS-CoV-2) |
| MINERVA (GitLab) |
Apoptosis pathway
(GitLab) JNK pathway (GitLab) ETC disruption (GitLab) |
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|
Integrative stress response: Renin-angiotensin system |
WikiPathways | WP4883, WP4965 | S (SARS-CoV-2) |
| MINERVA (GitLab) | Renin-angiotensin pathway (GitLab) | ||
|
Integrative stress response: Coagulopathy |
WikiPathways | WP4927 | S (SARS-CoV-2) |
| MINERVA (GitLab) | Coagulation pathway (GitLab) | ||
|
Innate Immune Response: PAMP signalling |
WikiPathways | WP4912 | nsp3, nsp15, Orf3b, Orf8, Orf9, M, N, S (SARS-CoV-1) |
| MINERVA (GitLab) | PAMP signalling (GitLab) | ||
|
Innate Immune Response: Induction of interferons and the cytokine storm |
WikiPathways | WP4868, WP4880, WP4876 |
4a, 4b, PLPro, S (MERS) nsp3, nsp13, Orf3a, Orf6, Orf7a, Orfab, Orfb, M, N, S (SARS-CoV-1) |
| MINERVA (GitLab) | Interferon I pathway | ||
|
Innate Immune Response: Altered host metabolism |
WikiPathways | WP4853 | Nsp14, Orf3a, E, M, N, S (SARS-CoV-2) |
| MINERVA (GitLab) |
Heme Oxygenase pathway
(GitLab) Kynurenine synthesis pathway (GitLab) Amino sugar and nucleotide sugar metabolism (GitLab) Pyrimidine deprivation pathway (GitLab) |
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