How to browse COVID-19 Disease Map diagrams:
| Pathway | Diagrams | Virus proteins | |
|---|---|---|---|
| Resource | Access | ||
| Virus replication cycle: Attachment and entry | WikiPathways | WP4846 | All |
| Reactome | R-HSA-9678110, R-HSA-9694614 | ||
| MINERVA (GitLab) | Virus replication cycle (GitLab) | ||
| Virus replication cycle: Transcription, translation and replication | WikiPathways | WP4846 | All |
| Reactome | R-HSA-9679504, R-HSA-9694676 R-HSA-9679514, R-HSA-9694682 R-HSA-9683701, R-HSA-9694635 | ||
| MINERVA (GitLab) | Virus replication cycle (GitLab) RTC and transcription (GitLab) Nsp9 interactions (GitLab) E protein interactions (GitLab) | ||
| Virus replication cycle: Assembly and release | Reactome | R-HSA-9679509, R-HSA-9694322 | All |
| MINERVA (GitLab) | Virus replication cycle (GitLab) Nsp4 and Nsp6 interactions (GitLab) | ||
| Viral subversion of host defence: ER stress and unfolded protein response | WikiPathways | WP4861 | S (HCoV OC43) 4a (MERS) Orf8ab, E, nsp15 (SARS-CoV-1) |
| MINERVA (GitLab) | ER stress (GitLab) | ||
| Viral subversion of host defence: Autophagy and protein degradation | WikiPathways | WP4860, WP4936, WP4863 | nsp6 (SARS-CoV-1) nsp567 (PRRSV) Nsp6, Orf3, Orf10 (SARS-CoV-2) |
| MINERVA (GitLab) | Orf10 Cul2 pathway (GitLab) | ||
| Viral subversion of host defence: Apoptosis | WikiPathways | WP4864 | Orf3a, Orf3b, Orf6, Orf8a, Orf7a, Orf9b, E, M, N, S (SARS-CoV-1) Nsp4. Nsp5, Nsp6. Nsp7, Nsp8, Orf9c (SARS-CoV-2) |
| MINERVA (GitLab) | Apoptosis pathway (GitLab) JNK pathway (GitLab) ETC disruption (GitLab) | ||
| Integrative stress response: Renin-angiotensin system | WikiPathways | WP4883, WP4965 | S (SARS-CoV-2) |
| MINERVA (GitLab) | Renin-angiotensin pathway (GitLab) | ||
| Integrative stress response: Coagulopathy | WikiPathways | WP4927 | S (SARS-CoV-2) |
| MINERVA (GitLab) | Coagulation pathway (GitLab) | ||
| Innate Immune Response: PAMP signalling | WikiPathways | WP4912 | nsp3, nsp15, Orf3b, Orf8, Orf9, M, N, S (SARS-CoV-1) |
| MINERVA (GitLab) | PAMP signalling (GitLab) | ||
| Innate Immune Response: Induction of interferons and the cytokine storm | WikiPathways | WP4868, WP4880, WP4876 | 4a, 4b, PLPro, S (MERS) nsp3, nsp13, Orf3a, Orf6, Orf7a, Orfab, Orfb, M, N, S (SARS-CoV-1) |
| MINERVA (GitLab) | Interferon I pathway | ||
| Innate Immune Response: Altered host metabolism | WikiPathways | WP4853 | Nsp14, Orf3a, E, M, N, S (SARS-CoV-2) |
| MINERVA (GitLab) | Heme Oxygenase pathway (GitLab) Kynurenine synthesis pathway (GitLab) Amino sugar and nucleotide sugar metabolism (GitLab) Pyrimidine deprivation pathway (GitLab) | ||